Mendelian Randomization
Mendel randomization (MR) is a method of an epidemiologic study, which uses genetic variants as instrument proxy to provide the causal inference of risk factors and outcome diseases, thus avoiding the limitations of costly and intricately randomized observational trials.
We performed two-sample MR analyses to explore the causal relationships between brain IDPs and psychiatric disorders with the valid IVs. Two-sample MR method requires two independent GWAS statistics with unrelated participants. We conducted inverse-variance weighted (IVW) regression as the primary causal inference model.
